• Multifactoral inheritance pattern
  • Most often in men older than 30 years old
  • due to either over production or under excretion of uric acid
  • Clinical
    • Commonly occurs in first toe (podagra)
    • Asymetric joint distribution
    • swollen, red and painful
    • tophus formation
    • acute attacks after alcohol consumption
  • Pathology
    • precipitate of monosodium urate crystals into joints
    • crystals are needle shaped and negatively birefringent
  • Treatment
    • allopurinol - blocks xanthine oxidase —> d/c production
    • probenecid - increases excretion by inhibiting reabsorption of uric acid
    • colchicine - depolymerizes microtubules impairing chemotaxis and degranulation (d/c inflammation)
Unless otherwise stated, the content of this page is licensed under Creative Commons Attribution-ShareAlike 3.0 License