Grave's Disease
  • common cause of hyperthyroidism
  • IgG antibodies against TSH receptors stimulate the thyroid gland
    • A type II hypersensitivity
  • association with HLA DR3
  • Pathology
    • Symetrical thyromegaly
      • papillary projections in thyroid folliciles and lymphoid aggregates in the stroma
      • scalloping of the colloid
  • Clinical
    • exophthalmos & pretibial myxedema
      • caused by glycosaminoglycans deposited in the tissues
    • Often presents during stress
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