Ischemic ATN

• Common type of ATN
• Most often caused by prerenal axotemia due to hypovolemia
• any drop is CO can cause Ischemic ATN

• Pathology
  • ischemia damages the endothelial cells —> decrease GFR
  • ischemia damages the tubule cells —> renal tubular casts/muddy brown casts
  • sites of damage: proximal tubule & thick ascending limb in non-focal pattern
  • rupture of basement membrane

• Clinical
  • Reversible, but fatal if untreated
  • death most often occurs in early oliguric phase